Immunoexpression of ALDH1A1, FGFR2, CD44 and Caspase-3 in Oral Squamous Cell Carcinoma and Leukoplakia: A Pilot Study

Current research highlighted the importance to recognize feasible biomarkers for early diagnoses and treatment in oral cancer. Our study analyzed expression spatial distribution of ALDH1A1, FGFR2, caspase-3, CD44 Oral Squamous Cell Carcinoma (OSCC) leukoplakia with without mucosal dysplasia. Paraffin-embedded samples OSCC (n=5), (n=5) dysplasia obtained by incisional biopsies were processed using conventional histochemical techniques. Immunohistochemistry was performed antibodies against CD44. Images immunohistochemically stained tissue sections according intensity immunostaining each marker classified Scores. The Kruskal-Wallis test (p≤0.05). results demonstrated a statically difference all immunomarkers between dysplasia, being more significant FGFR2 ALDH1A1. Within limitations this study, our data showed that overexpressed mucosa suggesting presence is clinic-pathologic predictor malignant transformation.